Adverse Maternal Metabolic Intrauterine Environment and Placental Epigenetics: Implications for Fetal Metabolic Programming
نویسندگان
چکیده
منابع مشابه
Maternal obesity and fetal metabolic programming: a fertile epigenetic soil.
The incidence of obesity and overweight has reached epidemic levels in the United States and developed countries worldwide. Even more alarming is the increasing prevalence of metabolic diseases in younger children and adolescents. Infants born to obese, overweight, and diabetic mothers (even when normal weight) have increased adiposity and are at increased risk of later metabolic disease. In ad...
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Fetal metabolic programming is a concept first suggested by Barker and Hales (1,2) in the early 1990s. On the basis of compelling epidemiological evidence, they hypothesized that fetal and perinatal events, such as maternal undernutrition, were central to determine one’s risk to develop chronic metabolic diseases. Such conditions, including obesity, diabetes, and cardiovascular diseases, have b...
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Host/Regulation in Metabolism Group/Nutrient Society Macronutrient Group Joint Colloquium Dedicated to Professor Ray Dils (Reading) on the Occasion of His Retirement. Organized by P. Quant (Unit of Paediatric Surgery, University College London Medical School), C. Skidmore (School of Animal and Microbial Sciences, University of Reading), J. Morgan (School of Biological Sciences, University of Su...
متن کاملFetal, maternal, and placental sources of serotonin and new implications for developmental programming of the brain.
In addition to its role in neurotransmission, embryonic serotonin (5-HT) has been implicated in the regulation of neurodevelopmental processes. For example, we recently showed that a subset of 5-HT1-receptors expressed in the fetal forebrain mediate a serotonergic modulation of thalamocortical axons response to axon guidance cues, both in vitro and in vivo. This influence of 5-HT signaling on f...
متن کاملMaternal calcium metabolic stress and fetal growth.
BACKGROUND Suboptimal maternal calcium intake and vitamin D status may or may not adversely influence fetal growth. OBJECTIVE It was hypothesized that maternal calcium metabolic stress in early pregnancy, rather than suboptimal calcium intake or insufficient vitamin D, influences the risk of small-for-gestational-age (SGA) births and other aspects of fetal growth. Stress to calcium metabolism...
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ژورنال
عنوان ژورنال: Current Environmental Health Reports
سال: 2018
ISSN: 2196-5412
DOI: 10.1007/s40572-018-0217-9